Associate Scientist / Scientist, Preclinical DMPK In Vivo

Neurocrine Biosciences
United States, California, San Diego
Jan 28, 2025
Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (in collaboration with AbbVie) About the Role: As a member of the Preclinical DMPK organization, the candidate will be responsible for conducting in vivo rodent experiments for pharmacokinetic assessment of drug candidates to support drug discovery and development activities. Specifically, the position is responsible for handling rodents in a laboratory and dosing test material (small molecules, peptides, and proteins) via multiple routes of administration and collecting biospecimens for subsequent bioanalysis. This position collaborates with cross-functional teams within DMPK as well as Research Biology, Medicinal Chemistry, and other departments on projects pertaining to pharmacokinetic studies. A successful candidate will have strong technical skills, a keen attention to detail, and the ability to work independently and as part of a team. _ Your Contributions (includes, but not limited to): Perform rat and mouse in vivo pharmacokinetic studies that support preclinical programs in the neurology and endocrinology disease space Handles and doses animals in a laboratory setting Administer small molecule, peptide and biologics drug candidates to rodents (mouse and rat) via multiple routes of administration, measure endpoints and collect biospecimens Design and write study protocol, follow IACUC protocols, SOP and animal welfare policy in animal studies Recommends alternatives, researches new methods and techniques and may proactively seek out senior personnel to discuss potential solutions to problems Maintain accurate and detailed experimental records, adding records to an ELN Completes data analysis and reporting. Maintains and updates SOPs and writes data summaries and reports for experiments conducted Maintain and edit pivotal metrics in Smartsheet to support program timelines Maintain and catalog compounds and samples for dosing or when shipping externally Maintain stock of lab supplies to ensure timely execution of studies Requirements: BS/BA degree in biological sciences, pharmacology or biopsychology and 2+ years of experience in the handling and dosing of rodents in a laboratory setting OR MS/MA degree in biological sciences, pharmacology or biopsychology and some relevant experience preferred Extensive hands-on experience in rodent handling, compound administration via different routes (PO, IP, SC, IM), sampling tissues and the processing of those tissues Experience in writing in vivo study reports and ELN Recognizes fundamental anomalies in data points and identifies issues in experiments/processes Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals Have knowledge of the principles of animal physiology, biology and chemistry, including pharmacology Have good knowledge and demonstrated ability working with a variety of laboratory equipment Must have working knowledge of Microsoft Office Must be detail oriented and have good time management skills Ability to meet multiple deadlines, with a high degree of accuracy and efficiency Have good communication, problem-solving and analytical thinking skills Ability to work as part of a team #LI-OB1 Neurocrine Biosciences is an EEO/AA/Disability/Vets employer. We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description. _ The annual base salary we reasonably expect to pay is $88,000.00-$127,550.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.