Modeling & Simulations Senior Scientist-(Remote)

Job Description

General Summary:

The Modeling & Simulations Senior Scientist at Vertex will lead Modeling & Simulation analyses from planning through reporting and align these analyses with the strategy determined by the modeling program lead. Types of analyses can include modeling and simulation to support evaluation of study design, dose selection, probability of success estimation, portfolio strategy, pediatric extrapolation etc. It is expected that this role will work in close collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research and other colleagues within the R&D organization The M&S Senior Scientist contributes to evaluation of study design, dose selection, probability of success estimation, portfolio strategy, pediatric extrapolation etc.

Key Duties and Responsibilities:

• Development and execution of Modeling & Simulation plans and analyses fully integrated with the overall development plans
• By using state of the art Modeling & Simulation methodologies, strongly contribute to critical decision making like study design, dose selection, probability of success estimation, etc.
• Contribute to the continuous improvement in efficiency and effectiveness of our M&S capability by supporting training activities, evaluating and incorporating new M&S tools as appropriate
• Perform mechanism based PKPD and population PK and PK/PD analyses, clinical trial simulations, translational modeling (preclinical - clinical) and other model-based analyses in collaboration with other scientists on a regular basis
• Contribute M&S expertise to multiple projects, including as the lead representative for specific analyses and evaluate and interpret analysis results
• Contribute to the continuous improvement in efficiency and effectiveness of our M&S capability by supporting training activities, evaluating and incorporating new M&S tools as appropriate
• Organizes and participates in departmental functions and represents the department in company-wide, non-scientific initiatives
• Integrate modeling into decision making by clearly communicating key results

Knowledge and Skills:

• Strong experience working in clinical development teams and integrating the use of PK/PD modeling and/or modeling of complex biological system
• A deep understanding of biology, pharmacokinetic and quantitative pharmacology (PKPD) principles
• In-depth hands-on skills in population PK and PKPD modeling, mechanistic PKPD modeling, Clinical trial simulations, Disease progression modeling, etc.
• Advanced skills in the use of NonMem, PsN, R, and similar tools
• Excellent, verbal and written communication skills
• Experience with biologics preferred

Education and Experience:

• Master's or PhD, with preference in Pharmaceutical sciences, Pharmacometrics, mathematics, statistics, or other quantitative discipline with an emphasis on Pharmacometrics and PKPD modeling
• Typically requires the following: PhD and 3 years experience or Master's Degree and 6 years experience in the application of Pharmacometric and other Modeling methodologies in the context of drug research & development in industry, academia or regulatory agencies.

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Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this Remote-Eligible role, you can choose to be designated as:
1. Remote: work remotely five days per week and come into the office on occasion - you're always welcome on-site; or select
2. Hybrid: work remotely up to two days per week; or select
3. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com