New

Research Scientist, Non-Viral Delivery - Biologics

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
May 14, 2025
Job Description Vertex is seeking a talented Research Scientist to join a collaborative research team focused on non-viral delivery within Vertex Cell and Genetic Therapies (CGT) in Boston, MA. The group's mission is to deliver the next generation genetic therapies impacting several therapeutic areas. We are looking for a candidate with a strong desire to deliver innovative new medicines to patients in need. In this lab-based role, the ideal candidate is strongly experienced in biologics engineering, bioconjugation of antibodies and antibody-like scaffolds, biologics purification and characterization, and structure/function relationships. Prior experience in lipid nanoparticle formulation and biologics discovery are strongly preferred. The candidate should be independent, accustomed to taking initiative, and bring enthusiasm and intellectual curiosity to Vertex's fast-paced research environment. Key Responsibilities: Work collaboratively amongst several project teams to deliver complex bioconjugates using a variety of conjugation chemistries to a wide set of novel biologic formats Develop, execute and optimize small- and large-scale conjugation and purification processes to enable key program milestones Develop, execute, and interpret assays to establish protein and bioconjugate physiochemical properties Design, engineer, characterize fit-for-purpose antibody and antibody-like scaffolds Structure/function relationships of biologic/target interactions to improve desired characteristics Active participation in group and cross-disciplinary project team meetings Knowledge and Skills: Experience working within integrated drug discovery teams Hands-on experience in protein purification (affinity, SEC, ion exchange, TFF) is required Experience in bio-layer interferometry, SPR, DLS, and HPLC-based characterization methods Experience with liposomes, lipid nanoparticles, or other delivery vehicles Track record of productivity as evidenced by a strong publication record Self-motivation, organization, and ability to communicate effectively Candidate Requirements: Ph.D. with 0-3 years of relevant protein biochemistry experience. Strong candidates with a BS or MS with extensive relevant experience will also be considered. Pay Range: $104,200 - $156,300 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com